serum tnf-α, il-10 and il-2 in schizophrenic patients before and after treatment with risperidone and clozapine
نویسندگان
چکیده
background: schizophrenia is a disorder of the executive function of both sensory and central nervous system. recent studies suggest that immune mechanisms play a role in the pathophysiology of this disease. the variations in cytokine concentrations have been associated with psychopathology and treatment of schizophrenia. objective: to investigate the changes in serum concentrations of tnf- α, il-10, and il-2 in schizophrenic patients before and 40 days after treatment. methods: in a case-control study, 26 schizophrenic patients and 26 healthy individuals were enrolled as the control group. panss scale questionnaire was used for diagnosis and assessing the severity of the disease. all patients were then treated with risperidone or clozapine for 40 days. serum concentrations of tnf- α, il-10 and il-2 were measured by elisa before and after treatment in both groups. paired t-test and independent t-test were used for comparison of data. results: comparison of tnf-α and il-10 concentrations in patients before and after treatment revealed a significance decrease of tnf- α and increase of il-10 concentrations (p=0.002, and p=0.008, respectively). serum concentrations of il-2 were lower than the detection limit of assay and were not detectable. in comparison with healthy controls, serum concentrations of tnf- α in schizophrenic patients were higher, while il-10 concentrations were lower before treatment although the differences were not significant (p=0.291 and p=0.375, respectively). there was no correlation between cytokine concentrations and the positive and negative scale (panss). also no significant difference in the admission, relapses, and duration of illness before and after treatment was observed. conclusions: increase of tnf- α and decrease of il-10 may have an important role inpsychopathology of schizophrenia.
منابع مشابه
Serum TNF-α, IL-10 and IL-2 in Schizophrenic Patients Before and After Treatment with Risperidone and Clozapine
Background: Schizophrenia is a disorder of the executive function of both sensory and central nervous system. Recent studies suggest that immune mechanisms play a role in the pathophysiology of this disease. The variations in cytokine concentrations have been associated with psychopathology and treatment of schizophrenia. Objective: To investigate the changes in serum concentrations of TNF- α, ...
متن کاملSerum TNF-α, IL-10 and IL-2 in schizophrenic patients before and after treatment with risperidone and clozapine.
BACKGROUND Schizophrenia is a disorder of the executive function of both sensory and central nervous system. Recent studies suggest that immune mechanisms play a role in the pathophysiology of this disease. The variations in cytokine concentrations have been associated with psychopathology and treatment of schizophrenia. OBJECTIVE To investigate the changes in serum concentrations of TNF-α, I...
متن کاملNegative Correlation between Serum S100B and Leptin Levels in Schizophrenic Patients During Treatment with Clozapine and Risperidone: Preliminary Evidence
Recently, extensive efforts have been made to understand the rate of energy expenditure and the weight gain associated with atypical antipsychotic treatment, including identification of markers of obesity risk. In recent years, leptin, an adipocyte hormone, has gained significant interest in psychiatric disorders. S100B has been considered as a surrogate marker for astrocyte-specific damage in ...
متن کاملNegative Correlation between Serum S100B and Leptin Levels in Schizophrenic Patients During Treatment with Clozapine and Risperidone: Preliminary Evidence
Recently, extensive efforts have been made to understand the rate of energy expenditure and the weight gain associated with atypical antipsychotic treatment, including identification of markers of obesity risk. In recent years, leptin, an adipocyte hormone, has gained significant interest in psychiatric disorders. S100B has been considered as a surrogate marker for astrocyte-specific damage in ...
متن کاملEffect of sitagliptin on serum levels of TNF-α, IL-1β and IL-10 in patients with type 2 diabetes mellitus
Introduction: Type 2 diabetes mellitus (T2DM) is an inflammatory disease with alterations in immune system. Remarkably, cytokine imbalance plays an important role in pathogenesis of T2DM. The purpose of this study was to determine the serum levels of TNF-α, IL-1β and IL-10 and the effects of sitagliptin on the level of these cytokines in patients with T2DM. Materials and Methods: Blood samples ...
متن کاملElevated Serum Levels of IL-6 and TNF-α in Patients with Irritable Bowel Syndrome
Introduction: Irritable bowel syndrome (IBS) is accompanied by abdominal pain and intestinal discomforts. A line of evidence shows that the immune system plays important roles in the pathogenesis of the disease. Two main cytokines directing the immune system are IL-6 and TNF-α which may play a role in the immunopathogenesis of this disease. The present study aimed at investigating the serum lev...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of immunologyجلد ۱۱، شماره ۳، صفحات ۲۰۰-۲۰۹
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023